Healthcare
❯
Treatment recommendation
❯Medical Assistants
❯AI-based mapping of optical to multi-electrode catheter recordings for atrial fibrillation treatment
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AI-based mapping of optical to multi-electrode catheter recordings for atrial fibrillation treatment
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AI-based mapping of optical to multi-electrode catheter recordings for atrial fibrillation treatment
For:
Hospitals, cardiologistsGoal:
Improved Product Development / R&DProblem addressed
Given: Recordings from multi-electrode catheter grid, with ground-truth labels from near-infrared optical mapping, obtained from explanted hearts.
Output: Possibility of recordings to be from source (driver) region of atrial fibrillation.
Scope of use case
Predicting possible targets for atrial fibrillation ablation based on explanted human heart data of two modalities (multi-electrode mapping and near-infrared optical imaging)
Description
Atrial fibrillation (AF) is the most common cardiac
arrhythmia and the leading cause of stroke. The success rate
of current AF treatment is low, 50-70 %. Several
experimental and clinical studies suggest that AF may be
caused and maintained by micro-anatomic intramural re-
entry called drivers. Physical destruction of the driver, or
driver ablation, leads to the termination of AF. Unfortunately,
the current clinical method to look for drivers (MEM) suffers
from many limitations, including poor resolution and only-
surface tissue mapping. On the other hand, near-infrared
optical mapping (NIOM) has one thousand times higher
resolution and records electrical activity from the depth of
atrial tissue (up to 5 mm), but needs specific voltage-
sensitive dye to color the tissue and therefore can be used
only for explanted specimens. For our research, we used
unique data of the experiments with explanted human atria
from Ohio State University simultaneous recordings of AF
episodes by MEM and NIOM. In this work, we predicted the
possibility of AFib drivers to be visible in the MEM recording
as trained by the Optical ex-vivo data. We created the
machine learning classifier with ground-truth labels based
on NIOM maps. As features, we used characteristics from the
Fourier spectra of MEM recordings. Our experiments on a
dataset of more than 20 000 spectra provided an accuracy
and f1-score of 97,3 % and 0,89, respectively.
Machine Learning
AI: Understand